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Background  Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRH CSF  was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chronic pain and fatigue states. CRH CSF  was first correlated with demographic, vital sign, HPA axis, validated questionnaire domains, baseline and maximal responses to pain, exercise and other stressors. Significant factors were used for linear regression modeling.    Results  Highly significant correlations were found despite the small number of subjects. Three models were defined: (a) CRH CSF  with blood glucose and sodium (explained variance = 0.979, adjusted R 2  = 0.958, p = 0.02 by 2-tailed testing); (b) CRH CSF  with resting respiratory and heart rates (R 2  = 0.963, adjusted R 2  = 0.939, p = 0.007); and (c) CRH CSF  with SF-36 Vitality and Multidimensional Fatigue Inventory Physical Fatigue domains (R 2  = 0.859, adjusted R 2  = 0.789, p = 0.02).    Conclusions  Low CRH CSF  was predicted by lower glucose, respiratory and heart rates, and higher sodium and psychometric constructs of well being. Responses at peak exercise and to other acute stressors were not correlated. CRH CSF  may have reflected an overall, or chronic, set-point for physiological responses, but did not predict the reserves available to respond to immediate stressors.

Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans.