English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Mutations associated with resistance to rifampin or streptomycin have been reported for W/Beijing and Latin American Mediterranean (LAM) strain families of  Mycobacterium tuberculosis . A few studies with limited sample sizes have separately evaluated mutations in  kat G,  ahp C and  inh A genes that are associated with isoniazid (INH) resistance. Increasing prevalence of INH resistance, especially in high tuberculosis (TB) prevalent countries is worsening the burden of TB control programs, since similar transmission rates are noted for INH susceptible and resistant  M. tuberculosis  strains.    Results  We, therefore, conducted a comprehensive evaluation of INH resistant  M. tuberculosis  strains (n = 224) from three South American countries with high burden of drug resistant TB to characterize mutations in  kat G,  ahp C and  inh A gene loci and correlate with minimal inhibitory concentrations (MIC) levels and spoligotype strain family. Mutations in  kat G were observed in 181 (80.8%) of the isolates of which 178 (98.3%) was contributed by the  katG  S315T mutation. Additional mutations seen included  oxy R- ahp C;  inh A regulatory region and  inh A structural gene. The S315T  kat G mutation was significantly more likely to be associated with MIC for INH ≥2 μg/mL. The S315T  kat G mutation was also more frequent in Haarlem family strains than LAM (n = 81) and T strain families.    Conclusion  Our data suggests that genetic screening for the S315T  kat G mutation may provide rapid information for anti-TB regimen selection, epidemiological monitoring of INH resistance and, possibly, to track transmission of INH resistant strains.

bmc microbiology

Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosisclinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America