English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Most extracellular virulence factors produced by  Bacillus cereus  are regulated by the pleiotropic transcriptional activator PlcR. Among strains belonging to the  B. cereus  group, the  plcR  gene is always located in the vicinity of genes encoding the YvfTU two-component system. The putative role of YvfTU in the expression of the PlcR regulon was therefore investigated.    Results  Expression of the  plcR  gene was monitored using a transcriptional fusion with a  lacZ  reporter gene in a  yvfTU  mutant and in its  B. cereus  ATCC 14579 parental strain. Two hours after the onset of the stationary phase, a stage at which the PlcR regulon is highly expressed, the  plcR  expression in the  yvfTU  mutant was only 50% of that of its parental strain. In addition to the reduced  plcR  expression in the  yvfTU  mutant, a few members of the PlcR regulon showed a differential expression, as revealed by transcriptomic and proteomic analyses. The virulence of the  yvfTU  mutant in a  Galleria mellonella  insect model was slightly lower than that of the parental strain.    Conclusion  The YvfTU two-component system is not required for the expression of most of the virulence factors belonging to the PlcR regulon. However, YvfTU is involved in expression of  plcR , a major regulator of virulence in  B. cereus .

The YvfTU Two-component System is involved in plcR expression in Bacillus cereus