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Background  B-Cell Activating Factor (BAFF) is a cytokine regulating antibody production. Polymorphisms in the gene encoding BAFF were associated with the antibody response to  Ascaris  but not to mite allergens. In the present study we evaluated the relationship between BAFF and specific antibodies against  Ascaris  and mites in 448 controls and 448 asthmatics. Soluble BAFF was measured by ELISA and  BAFF  mRNA by qPCR. Surface expression of BAFF and its receptor (BAFF-R) was analyzed by flow cytometry.    Results  Individuals with specific IgE levels to  Ascaris  >75th percentile had lower levels of soluble BAFF; those with specific IgG levels to  Ascari s >75th percentile had reduced  BAFF  mRNA. Total IgE and specific IgE to mites were not related to BAFF levels. There were no differences in soluble BAFF or mRNA levels between asthmatics and controls. There was an inverse relationship between the cell-surface expression of BAFF-R on CD19 +  B cells and BAFF levels at the transcriptional and protein level.    Conclusions  These findings suggest that differences in BAFF levels are related to the strength of the antibody response to  Ascaris .

The strength of the antibody response to the nematode Ascaris lumbricoides inversely correlates with levels of B-Cell Activating Factor (BAFF)