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Background  Substantial gene substitution effects on milk production traits have formerly been reported for alleles at the K232A and the promoter VNTR loci in the bovine acylCoA-diacylglycerol-acyltransferase 1 ( DGAT1 ) gene by using data sets including sires with accumulated phenotypic observations of daughters (breeding values, daughter yield deviations). However, these data sets prevented analyses with respect to dominance or parent-of-origin effects, although an increasing number of reports in the literature outlined the relevance of non-additive gene effects on quantitative traits.    Results  Based on a data set comprising German Holstein cows with direct trait measurements, we first confirmed the previously reported association of  DGAT1  promoter VNTR alleles with milk production traits. We detected a dominant mode of effects for the  DGAT1  K232A and promoter VNTR alleles. Namely, the contrasts between the effects of heterozygous individuals at the  DGAT1  loci differed significantly from the midpoint between the effects for the two homozygous genotypes for several milk production traits, thus indicating the presence of dominance. Furthermore, we identified differences in the magnitude of effects between paternally and maternally inherited  DGAT1  promoter VNTR – K232A haplotypes indicating parent-of-origin effects on milk production traits.    Conclusion  Non-additive effects like those identified at the bovine  DGAT1  locus have to be accounted for in more specific QTL detection models as well as in marker assisted selection schemes. The  DGAT1  alleles in cattle will be a useful model for further investigations on the biological background of non-additive effects in mammals due to the magnitude and consistency of their effects on milk production traits.

bmc genomic data

Dominance and parent-of-origin effects of coding and non-coding alleles at the acylCoA-diacylglycerol-acyltransferase (DGAT1) gene on milk production traits in German Holstein cows