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Background  Growth-related traits have been mapped on bovine chromosome 6 (BTA 6) in various bovine breed populations. We previously mapped a significant quantitative trait locus (QTL) for carcass and body weight ( CW-2 ) between 38 and 55 cM on BTA 6 using a Japanese Black half-sib family. Additional QTL mapping studies detected four QTL for body or carcass weight that overlapped with  CW-2  in Japanese Black and Japanese Brown half-sib families. To map the region in greater detail, we applied cross-breed comparisons of haplotypes that have been shown to be powerful in canine.    Results  We used 38 microsatellite markers to search for a shared  Q  (increasing carcass and/or body weight) haplotype within the 17-cM  CW-2  region among five sires. Linkage disequilibrium mapping using maternal alleles of the offspring showed that an 815-kb shared  Q  haplotype was associated with body or carcass weight in both breeds. The addition of 43 single nucleotide polymorphism (SNP) markers narrowed the region to 591 kb containing 4 genes. The SNP changing Ile-442 to Met in  NCAPG  (chromosome condensation protein G) was significantly associated with carcass weight ( p  < 1.2 × 10 -11 ) in a large Japanese Black population as well as in the five families. The  Q  allele of the SNP was also associated with a larger longissimus muscle area and thinner subcutaneous fat thickness in steers of all five families, indicating that the  CW-2  locus is pleiotropic and favorable for marker-assisted selection of beef cattle.    Conclusion  A 591-kb critical region for  CW-2  was identified. The SNP changing Ile-442 to Met in  NCAPG  (chromosome condensation protein G) can be used as a positional candidate of  CW-2  for marker-assisted selection.

bmc genomic data

Cross-breed comparisons identified a critical 591-kb region for bovine carcass weight QTL (CW-2) on chromosome 6 and the Ile-442-Met substitution in NCAPG as a positional candidate