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Infusion of the nitric oxide (NO) donor, glyceryl trinitrate (GTN), provokes a migraine-like attack in migraineurs and cFos up-regulation in rat trigeminal nucleus caudalis. We studied the level of dura mast cell degranulation after infusion of GTN in awake, freely moving rats and hypothesized that the degranulation is secondary to NO.

EHMTI-0234. Glyceryl trinitrate provoked mast cell degranulation is secondary to the release of nitric oxide in vivo