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Hemiplegic migraine (HM) is a rare and severe subtype of autosomal dominant migraine, characterized by a complex aura including some degree of motor weakness. Mutations in three genes (CACNA1A, ATP1A2 and SCN1A) have been detected in familial and in sporadic cases. This genetically and clinically heterogeneous disorder is often accompanied by permanent ataxia, epileptic seizures, mental retardation, and chronic progressive cerebellar atrophy.

Screening of cacna1a and ATP1A2 genes in hemiplegic migraine: clinical, genetic and functional studies