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EGFR  and  HER2  mutations and  ALK  rearrangement are known to be related to lung cancer in never-smokers, while  KRAS ,  BRAF  and  PIK3CA  mutations are typically observed among smokers. There is still debate surrounding whether never-smokers exposed to passive smoke exhibit a “smoker-like” somatic profile compared with unexposed never-smokers.  Passive smoke exposure was assessed in the French BioCAST/IFCT-1002 never-smoker lung cancer cohort and routine molecular profiles analyses were compiled.  Of the 384 patients recruited into BioCAST, 319 were tested for at least one biomarker and provided data relating to passive smoking. Overall, 219 (66%) reported having been exposed to passive smoking. No significant difference was observed between mutation frequency and passive smoke exposure ( EGFR  mutation: 46% in never exposed  versus  41% in ever exposed;  KRAS : 7%  versus  7%;  ALK : 13%  versus  11%;  HER2 : 4%  versus  5%;  BRAF : 6%  versus  5%;  PIK3CA : 4%  versus  2%). We observed a nonsignificant trend for a negative association between  EGFR  mutation and cumulative duration of passive smoke exposure. No association was found for other biomarkers.  There is no clear association between passive smoke exposure and somatic profile in lifelong, never-smoker lung cancer.

No impact of passive smoke on the somatic profile of lung cancers in never-smokers