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From the authors:We thank K. Shah and Z. Udwadia for their comment on the joint systematic review and meta-analysis of the role of interferon-γ release assays (IGRAs) for the diagnosis of active tuberculosis (TB) by the Tuberculosis Network European Trials Group (TBNET) and the European Centre for Disease Prevention and Control [1]. It was demonstrated that immunodiagnosis by tuberculin skin testing and conventional IGRAs performed on cells from the peripheral blood, i.e. the QuantiFERON®-TB Gold In-Tube (Cellestis, Carnegie, Victoria, Australia) and the T-SPOT®. TB (Oxford Immunotec, Abingdon, UK) assays, has a limited role in …

Interferon- release assays for diagnosis of active pleural tuberculosis: a developing world perspective