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The purpose of bone tissue engineering is to employ scaffolds,cells, and growth factors to facilitate healing of bone defects. The aim of this studywas to assess the viability and osteogenic differentiation of primary human osteoblastsand adipose tissue–derived mesenchymal stem cells from various donors on titaniumdioxide (TiO2) scaffolds coated with an alginate hydrogel enriched with enamel matrixderivative. Cells were harvested for quantitative reverse transcription polymerase chainreaction on days 14 and 21, and medium was collected on days 2, 14, and 21 for proteinanalyses. Neither coating with alginate hydrogel nor alginate hydrogel enriched withenamel matrix derivative induced a cytotoxic response. Enamel matrix derivative–enrichedalginate hydrogel significantly increased the expression of osteoblast markers COL1A1,TNFRSF11B, and BGLAP and secretion of osteopontin in human osteoblasts, whereasosteogenic differentiation of human adipose tissue–derived mesenchymal stem cells seemedunaffected by enamel matrix derivative. The alginate hydrogel coating procedure may havepotential for local delivery of enamel matrix derivative and other stimulatory factorsfor use in bone tissue engineering

Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO2 scaffolds

Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO₂ scaffolds