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The success of pulpotomy of young permanent teeth depends on theproper selection of dressing materials. This study aimed to evaluate the histologicaland histomorphometric response of dentin–pulp complex to the enamel matrix derivative(Emdogain® gel) compared to that of calcium hydroxide when used as a pulp dressing inimmature young permanent dogs’ teeth. Dentin-like tissues bridging the full width of thecoronal pulp at the interface between the injured and healthy pulp tissues were seenafter 1 month in both groups. With time, the dentin bridge increased in thickness forcalcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group.Progressive inflammation and total pulp degeneration were only evident withEmdogain-treated group. The root apices of Emdogain-treated teeth became matured andclosed by cementum that attached to new alveolar bone by a well-oriented periodontalligament. In young permanent dentition, Emdogain could be a good candidate forperiodontium but not dentino–pulpal complex regeneration

Root maturation and dentin–pulp response to enamel matrix derivative in pulpotomized permanent teeth