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Alveolar bone regeneration is a significant challenge in dentalimplantation. Novel biomaterials and tissue-engineered constructs are under extensivedevelopment and awaiting in vivo animal tests to find clinical endpoint. Here, weestablish a novel in vivo model, modifying gingivoperiosteoplasty in rat for thealveolar bone regeneration. Rat premaxillary bone defects were filled with silk scaffoldor remained empty during the implantation period (up to 6 weeks), and harvested sampleswere analyzed by micro-computed tomography and histopathology. Empty defects showedincreased but limited new bone formation with increasing implantation period. In defectsimplanted with silk sponge, the bone formation was significantly greater than that ofempty defect, indicating an effective role of silk scaffold in the defect model. Themodified premaxillary defect model in rat is simple to perform, while mimicking theclinical conditions, finding usefulness for the development of biomaterials andtissue-engineered constructs targeting alveolar bone regeneration in dentalimplantation

A novel in vivo platform for studying alveolar bone regeneration in rat