English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective : To test the efficacy of a hyaluronan derivative (HYADD ® 4-G) in a model of osteoarthritis (anterior cruciate ligament [ACLT]) and to compare its efficacy with the injection of growth factors. Design : In a first experimental set-up, specially selected for treatment scheme with published studies on hyaluronan or growth factor efficacy in osteoarthritis, saline, HYADD ® 4-G, rh-BMP-7, and the treatments of rh-BMP-7 or rh-BMP-2 with HYADD ® 4-G were injected after ACLT, for five times starting 3 weeks after ACLT. Euthanasia was at day 70. The knees were evaluated by gross morphological observation, x-ray, and histology (Study A). In a second experimental set-up selected to evaluate the efficacy of three viscosupplement injections, starting 4 weeks after ACTL, HYADD ® 4-G was compared to saline (Study B). Results : (A) X-ray analysis showed more damage in the saline group than all other treatment groups (2.67 ± 0.61 for saline, 0.83 ± 0.26 for HYADD ® 4-G, 1.67 ± 0.82 for HYADD ® 4-G with rh-BMP-2, 0.75 ± 0.76 for HYADD ® 4-G with rh-BMP-7, and 1.58 ± 0.49 for rh-BMP-7), P &lt; 0.05. In the femoral condyle, the Mankin's score for HYADD ® 4-G with rh-BMP-2, HYADD ® 4-G with rh-BMP-7, and rh-BMP7 alone was statistically lower compared to saline in the medial part; in the lateral part a significant lower value was observed in the HYADD ® 4-G with the rh-BMP-2 group. (B) The Kellgren and Lawrence score and Mankin's score was lower in the HYADD ® 4-G group than in the saline group ( P &lt; 0.002 and P = 0.0031). Conclusions : These two studies suggest that HYADD ® 4-G delayed the cartilage degeneration and that the association of HYADD ® 4-G with growth factors is synergistic.

Efficacy Evaluation of a New Hyaluronan Derivative HYADD® 4-G to Maintain Cartilage Integrity in a Rabbit Model of Osteoarthritis

Efficacy Evaluation of a New Hyaluronan Derivative HYADD^® 4-G to Maintain Cartilage Integrity in a Rabbit Model of Osteoarthritis