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Background:   Self-monitoring of glucose is important for managing diabetes. Noninvasive glucose monitors are not yet available, but patients would benefit highly from such a device.Methods:   We present results that may lead to a novel, point-of-care noninvasive system to measure blood glucose based on Raman spectroscopy. A hospitalized cohort of 111 subjects was measured using a custom-made Raman spectrometer system. Blood glucose reference samples were used to correlate Raman data to glucose levels, using advanced preprocessing and analysis algorithms.Results:   A correlation coefficient ( R 2 ) of .83 was found correlating independent Raman-based predictions on reference blood glucose for the full cohort. Stratification of the cohort in gender-specific groups raised correlation levels to .88 (females) and .94 (males). Glucose could be measured noninvasively with average errors as low as 0.9 mM.Conclusion:   We conclude that this novel system shows promising results for the advance of noninvasive, point-of-care glucose monitoring.

Raman Spectroscopy as a Promising Tool for Noninvasive Point-of-Care Glucose Monitoring