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Objective:   This pilot study evaluated the difference in accuracy between the Bayer Contour® Next (CN) and HemoCue® (HC) glucose monitoring systems in children with type 1 diabetes participating in overnight closed-loop studies.Research Design and Methods:   Subjects aged 10-18 years old were admitted to a clinical research center and glucose values were obtained every 30 minutes overnight. Glucose values were measured using whole blood samples for CN and HC readings and results were compared to Yellow Springs Instrument (YSI) reference values obtained with plasma from the same sample. System accuracy was compared using mean absolute relative difference (MARD) and International Organization for Standardization (ISO) accuracy standards.Results:   A total of 28 subjects were enrolled in the study. Glucose measurements were evaluated at 457 time points. CN performed better than HC with an average MARD of 3.13% compared to 10.73% for HC ( P &lt; .001). With a limited sample size, CN met ISO criteria (2003 and 2013) at all glucose ranges while HC did not.Conclusions:   CN performed very well, and would make an excellent meter for future closed-loop studies outside of a research center.

Accuracy Evaluation of Blood Glucose Monitoring Systems in Children on Overnight Closed-Loop Control