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PET/CT imaging of clear cell renal cell carcinoma with 124I labeled chimeric antibody
Author(s) -
Eamonn Bahnson,
Douglas A. Murrey,
Cathy M. Mojzisik,
Nathan C. Hall,
Humberto J. MartinezSuarez,
Michael V. Knopp,
Edward W. Martin,
Stephen P. Povoski,
Robert R. Bahnson
Publication year - 2009
Publication title -
therapeutic advances in urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.115
H-Index - 30
eISSN - 1756-2880
pISSN - 1756-2872
DOI - 10.1177/1756287209105264
Subject(s) - medicine , renal cell carcinoma , antibody , cancer research , pathology , nuclear medicine , immunology
Clear cell renal cell carcinoma (ccRCC) presents problems for urologists in diagnosis, treatment selection, intraoperative surgical margin analysis, and long term monitoring. In this paper we describe the development of a radiolabeled antibody specific to ccRCC (124I-cG250) and its potential to help urologists manage each of these problems. We believe 124I-cG250, in conjunction with perioperative Positron emission tomography/ computed tomography imaging and intraoperative handheld gamma probe use, has the potential to diagnose ccRCC, aid in determining a proper course of treatment (operative or otherwise), confirm complete resection of malignant tissue in real time, and monitor patients post-operatively.

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