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Objective:   To investigate the protective effect of repaglinide on rat with atherosclerosis.Methods:   Sprague Dawley (SD) rats were divided into control, model, repaglinide, and metformin groups. In addition to the normal group, rats were given intraperitoneal injection of streptozotocin and high-fat diet (HFD). Meanwhile, repaglinide or metformin was administrated to the treatment rats, respectively, for 4 weeks. Serum, plasma, liver, epididymal fat, and aorta thoracica were obtained to observe the protective effect of repaglinide on rat with atherosclerosis.Results:   Compared to the control group, blood glucose was increased in the model group ( P &lt; .05), while it was decreased in the drug-administered groups. In addition, the levels of endothelin 1, TG, TC, low-density lipoprotein cholesterol, atherogenic index, liver index, and epididymal fat index were significantly increased, but the levels of high-density lipoprotein cholesterol, plasminogen activator inhibitor 1, and antiatherogenic index were decreased significantly in the model group compared to the control group ( P &lt; .05, respectively). And these effects were reversed by treatment with repaglinide ( P &lt; .05, respectively).Conclusion:   Our results suggested that repaglinide may regulate the formation of early atherosclerosis through the abovementioned mechanisms.

Effect of Repaglinide on Blood Glucose, Endothelial Function, Lipid Metabolism, and Inflammatory Reaction in a Rat Model of Atherosclerosis