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This study evaluated the impact of influenza and vaccination coverage in Apulia, Italy, during the 2004–2005 and 2005–2006 seasons, using epidemiological and virological surveillance data collected through the Italian Net of Surveillance of Influenza (InfluNet) organized by the Superior Institute of Health (ISS) and the Inter-University Centre of Research on Influenza (CIRI). Vaccination coverage was calculated from the number of doses administered to individuals aged ≤ 65 years. Sentinel physicians reported weekly influenza-like illness (ILI) and acute respiratory illness (ARI) occurrences among patients. Influenza viruses were isolated and identified by cell culture on Madin-Darby Canine Kidney cells and polymerase chain reaction techniques. Vaccination coverage reached 72.7% and 77.0% during the 2004–2005 and 2005–2006 seasons, respectively. Incidence of ILI was higher during the 2004–2005 season compared with the 2005–2006 season, whereas the incidence ARI appeared to show a more constant trend. Incidence rates for ILI and ARI were higher in the 0 − 14-year age group. The increase in vaccination coverage and implementation of a network of epidemiological and virological surveillance are fundamental for the control and prevention of influenza.

Epidemiological and Virological Assessment of Influenza Activity in Apulia, Italy, during the Seasons 2004–2005 and 2005–2006