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The contractile effect of angiotensin II via AT1 receptors on the kidney arterioles is a crucial element in the kidney microcirculation. Angiotensin II also plays a role as an inhibitor via the AT1 receptors in the renin granulation of the arterioles. We have previously demonstrated that the AT1 receptors are downregulated in the renin-positive smooth muscle cells (SMCs) in contrast to renin-negative SMCs. In this study, we estimated the numbers of the AT1 receptor sub-types separately in the afferent and efferent arterioles and the renin-positive and renin-negative SMCs.

Up- and down-regulation of angiotensin II AT1-A and AT1-B receptors in afferent and efferent rat kidney arterioles

Up- and down-regulation of angiotensin II AT₁-A and AT₁-B receptors in afferent and efferent rat kidney arterioles