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Disability levels for patients with secondary progressive multiple sclerosis (SPMS) often worsen despite a stable MRI T(2) lesion burden. The presence of oxidative stress in the absence of measurable inflammation could help explain this phenomenon. In this study, the assessment of an in vivo marker of oxidative stress, cerebral glutathione (GSH), using magnetic resonance chemical shift imaging (CSI) is described, and GSH levels were compared in patients with SPMS and healthy controls.

multiple sclerosis

Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by <sup>1</sup>H magnetic resonance chemical shift imaging at 3 T

Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T

Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by ¹H magnetic resonance chemical shift imaging at 3 T