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Two hundred twenty-eight male broiler chicks (Columbia x New Hampshire) were given feed amended with autoclaved culture material of Fusarium proliferatum containing fumonisin B 1  (FB 1 ) at 61, 193, and 546 ppm, fumonisin B 2  (FB 2 ) at 14, 38, and 98 ppm, and moniliformin at 66, 193, and 367 ppm in 3 separate feeding trials (amounts of toxin in each trial, respectively). Birds were started on amended rations at days 1, 7, and 21 and continued on their respective ration until they were 28 days old. Purified FB 1  (125, 274 ppm) and moniliformin (27, 154 ppm) were given separately and in combination (137 and 77 ppm, respectively), starting on day 1 and continuing for 14 days. Of serum chemistry parameters, only glucose was significantly decreased. Significant increases were noted in serum cholesterol, sodium, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and γ-glutamyl transferase. Of the hematologic parameters, significant decreases were noted in red blood cell counts, hemoglobin, packed cell volume, and white blood cell counts. Immunologic changes included impaired anti-Newcastle disease antibody hemagglutination inhibition titers associated with relative decreases in total serum globulins and increases in albumin/globulin ratios. The changes were noted in all treatment groups when compared to controls.

journal of veterinary diagnostic investigation

Serohematologic Alterations in Broiler Chicks on Feed Amended with <i>Fusarium Proliferatum</i> Culture Material or Fumonisin B<sub>1</sub> and Moniliformin

Serohematologic Alterations in Broiler Chicks on Feed Amended with Fusarium Proliferatum Culture Material or Fumonisin B1 and Moniliformin

Serohematologic Alterations in Broiler Chicks on Feed Amended with Fusarium Proliferatum Culture Material or Fumonisin B₁ and Moniliformin