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Prion diseases are neurodegenerative diseases characterized by the accumulation of misfolded prion protein (PrP Sc ) in the brain and other tissues. Animal prion diseases include scrapie in sheep, chronic wasting disease (CWD) in cervids, and transmissible mink encephalopathy (TME) in ranch-raised mink. We investigated the susceptibility of raccoons to various prion disease agents and compared the clinicopathologic features of the resulting disease. Raccoon kits were inoculated intracranially with the agents of raccoon-passaged TME (TME Rac ), bovine-passaged TME (TME Bov ), hamster-adapted drowsy (TME DY ) or hyper TME (TME HY ), CWD from white-tailed deer (CWD Wtd ) or elk (CWD Elk ), or atypical (Nor98) scrapie. Raccoons were euthanized when they developed clinical signs of prion disease or at study endpoint (&lt;82 mo post-inoculation). Brain was examined for the presence of spongiform change, and disease-associated PrP Sc  was detected using an enzyme immunoassay, western blot, and immunohistochemistry. All raccoons inoculated with the agents of TME Rac  and TME Bov  developed clinical disease at ~6.6 mo post-inoculation, with widespread PrP Sc  accumulation in central nervous system tissues. PrP Sc  was detected in the brain of 1 of 4 raccoons in each of the CWD Wtd -, CWD Elk -, and TME HY -inoculated groups. None of the raccoons inoculated with TME DY  or atypical scrapie agents developed clinical disease or detectable PrP Sc  accumulation. Our results indicate that raccoons are highly susceptible to infection with raccoon- and bovine-passaged TME agents, whereas CWD isolates from white-tailed deer or elk and hamster-adapted TME HY  transmit poorly. Raccoons appear to be resistant to infection with hamster-adapted TME DY  and atypical scrapie agents.

journal of veterinary diagnostic investigation

Raccoons accumulate PrP<sup>Sc</sup> after intracranial inoculation of the agents of chronic wasting disease or transmissible mink encephalopathy but not atypical scrapie

Raccoons accumulate PrPSc after intracranial inoculation of the agents of chronic wasting disease or transmissible mink encephalopathy but not atypical scrapie

Raccoons accumulate PrP^Sc after intracranial inoculation of the agents of chronic wasting disease or transmissible mink encephalopathy but not atypical scrapie