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We have recently described the production of antisera which react with the human herpesvirus 6 (HHV-6) major capsid protein (MCP). We describe here the use of these specific antisera to characterize the kinetics of expression of the HHV-6 MCP and demonstrate that it is a late virus protein, expressed after DNA replication. We have used the expression of this protein as a measure of the efficacy of the antiviral nucleoside analogues 9-(2-hydroxyethoxymethyl)guanine (ACV) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) upon HHV-6 replication and have determined 50% inhibitory concentrations to be 150 μm and 2 μm, respectively.

The Use of Antisera to the Human Herpesvirus 6 Major Capsid Protein to Determine the Effect of Antiviral Inhibitors on Virus Gene Expression