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A retrospective study in coronary artery bypass graft patients was undertaken to assess the effect of gentamicin and a bypass prime with a high calcium on the incidence of renal failure. Patients who received both Haemaccel (polygeline, Hoechst Marion Roussel) (calcium concentration 6.25 mmol/l) in the bypass prime and gentamicin perioperatively had a higher incidence of renal failure compared with those who received only Haemaccel (P=0.005), only gentamicin (P=0.002) or neither (P=0.0001). We suggest that the combination be avoided in this group of patients.

Acute Renal Failure in Cardiac Surgical Patients, Potentiated by Gentamicin and Calcium