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We measured pulmonary clearance of aerosolised  99m  technetium-labelled diethylenetriaminepentacetate ( 99m Tc-DTPA) in thirty-four patients with acute respiratory dysfunction. Results were expressed as a half-time clearance from lung to blood (T ½ ). In sixteen non-smoking patients with acute lung injury, clearance was monoexponential, median T ½  11, range 4–40 min, and in five multi-exponential, median rapid T ½  3 min, with a slower median T ½  of 18 min (range 2–4 and 15–31 min respectively). Clearance was significantly (P   0.05) quicker than normal smokers previously studied (median T ½  20, range 6–73 min). One smoking lung-injured patient had an abnormal multi-exponential  99m Tc-DTPA clearance. Four patients with cardiogenic pulmonary oedema had T ½ s within the normal range. Repeated measurements made on nine patients with acute lung injury showed that clearance remained abnormally rapid despite improvements in lung radiographic appearance and gas exchange. We conclude that the  99m Tc-DTPA technique provides a virtually non-invasive measure of alveolar-capillary barrier dysfunction in non-smoking patients with acute lung injury.

Pulmonary Clearance of 99mTc-DTPA in the Diagnosis and Evolution of Increased Permeability Pulmonary Oedema

Pulmonary Clearance of ^99mTc-DTPA in the Diagnosis and Evolution of Increased Permeability Pulmonary Oedema