Open AccessImpact of Vibration on the Levels of Biomarkers: A Systematic Review
Author(s) -
Ashish Kumar Agrawal,
Chou Tm
Publication year - 2021
Publication title -
journal of indian orthodontic society/jios : journal of indian orthodontic society
Language(s) - English
Resource type - Journals
eISSN - 0974-9098
pISSN - 0301-5742
DOI - 10.1177/03015742211019520
Subject(s) - cochrane library , web of science , publication bias , meta analysis , medicine , forest plot , medline , psychology , computer science , biology , biochemistry
The objective of this systematic review is to assess the effect of vibrational force on biomarkers for orthodontic tooth movement.Methods: An electronic search was conducted for relevant studies (up to December 31, 2020) on the following databases: Pubmed, Google scholar, Web of Science, Cochrane Library, Wiley Library, and ProQuest Dissertation Abstracts and Thesis database. Hand searching of selected orthodontic journals was also undertaken. The selected studies were assessed for the risk of bias in Cochrane collaboration risk of bias tool. The “traffic plot” and “weighted plot” risk of bias distribution are designed in the RoB 2 tool. The 2 authors extracted the data and analyzed it.Results: Six studies fulfilled the inclusion criteria. The risks of biases were high for 4, low and some concern for other 2 studies. The biomarkers, medium, device, frequency and duration of device, as well as other data were extracted. The outcomes of the studies were found to be heterogenous.Conclusion: One study showed highly statistically significant levels of IL-1 beta with <.001. Rate of tooth movement was correlated with levels of released biomarkers under the influence of vibrational force in 3 studies, but it was found to be significant only in 1 study. It was further observed that vibration does not have any significant reduction in pain and discomfort.