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Sheep experimentally poisoned by ingestion of Astragalus letiginosus developed cytoplasmic vacuolation of the proximal tubular epithelia within 4 days after beginning of the experiment. Neuronal vacuolation occurred by day 8 and had progressed to neuronolysis by day 16.

Pathology of Locoweed (Astragalus lentiginosus) Poisoning in Sheep; Sequential Development of Cyloplasmie Vacuolation in Tissues