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Objective   To investigate the accuracy of derecruitment volume (V DER ) assessed by pressure–impedance (P-I) curves derived from electrical impedance tomography (EIT).Methods   Six pigs with acute lung injury received decremental positive end-expiratory pressure (PEEP) from 15 to 0 in steps of 5 cmH 2 O. At the end of each PEEP level, the pressure–volume (P-V) curves were plotted using the low constant flow method and release maneuvers to calculate the V DER  between the PEEP of setting levels and 0 cmH 2 O (V DER-PV ). The V DER  derived from P-I curves that were recorded simultaneously using EIT was the difference in impedance at the same pressure multiplied by the ratio of tidal volume and corresponding tidal impedance (V DER-PI ). The regional P-I curves obtained by EIT were used to estimate V DER  in the dependent and nondependent lung.Results   The global lung V DER-PV  and V DER-PI  showed close correlations (r = 0.948, P&lt;0.001); the mean difference was 48 mL with limits of agreement of −133 to 229 mL. Lung derecruitment extended into the whole process of decremental PEEP levels but was unevenly distributed in different lung regions.Conclusions   P-I curves derived from EIT can assess V DER  and provide a promising method to estimate regional lung derecruitment at the bedside.

Derecruitment volume assessment derived from pressure–impedance curves with electrical impedance tomography in experimental acute lung injury