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Objective  Pro-gastrin releasing peptide (ProGRP) plays an oncogenic role in small cell lung cancer (SCLC). The anti-ProGRP (31-98) monoclonal antibody D-D 3 can selectively accumulate in SCLC xenografts in nude mice. This study evaluated the effectiveness of a new pretargeting procedure for the early diagnosis of SCLC.    Methods  D-D 3 was radiolabeled with technetium-99m ( 99m Tc) using a three-step pretargeting method. Mice with SCLC xenografts were treated with different labeling regimens, and the biodistribution and radioimmunoimaging were explored. The percentage injected dose per gram (%ID/g) in various organs, tumor/non-tumor (T/NT) ratio, and tumor/background (T/B) ratio were also calculated.    Results  In vivo distribution experiments revealed that 99m Tc-DTPA-biotin was metabolized in the liver and kidney, with rapid elimination in the blood. The T/B ratio was highest in mice treated with biotinylated antibody D-D 3  + avidin +  99m Tc-DTPA-biotin. Single-photon emission computerized tomography imaging further confirmed that the T/B ratio was highest in this group at all time points.    Conclusions  In contrast to directly labeled D-D 3 , pretargeting technology displayed specific enhancement and signal amplification in tumors, which could increase the target tumor uptake of 99m Tc and provide a new approach for the early diagnosis of SCLC.

journal of international medical research

Pretargeted radioimmunoimaging with a biotinylated D-D<sub>3</sub>construct and<sup>99m</sup>Tc-DTPA-biotin: strategies for early diagnosis of small cell lung cancer

Pretargeted radioimmunoimaging with a biotinylated D-D3construct and99mTc-DTPA-biotin: strategies for early diagnosis of small cell lung cancer

Pretargeted radioimmunoimaging with a biotinylated D-D₃construct and^99mTc-DTPA-biotin: strategies for early diagnosis of small cell lung cancer