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This symposium synopsis summarizes key results from a 41-week study of diabetic nephropathy (DN) in the type 2 diabetic ZSF1 fa/fa CP  rat model. During this study, we conducted longitudinal analysis of biomarkers, renal histopathology, ultrastructural assessment, renal quantitative image analysis, and transcriptome analysis of glomerular-enriched tissue. We concluded that there is translational value for using the ZSF1 rat model in mechanistic and therapeutic intervention efficacy studies for type 2 DN.

41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/faCP Rat Model

41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/fa^CP Rat Model