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THE following distinct kinds of tumours should not be confused with one another: (1) Mixed tumours of adult tissues, e.g. of the breast, thyroid and uterus. (2) Embryonic tumours of particular organs, arising in early life from tissues which are still immature, e.g. embryonic tumours of the kidney, liver, and pelvic viscera. (3) Teratomas, composed of a variety of tissues quite foreign to the parts in which they arise. Tumours of the first class, e.g. mammary fibro-adenoma, contain both epithelial and non-epithelial neoplastic tissues. By serial transplantations of the mammary tumours of rats, several workers have found that the fibromatous component can be separated from the epithelial component and its properties studied, especially its sarcomatous transformation. Informative results might bobtained by similar transplantation of the common mammary fibro-adenomas of dogs, the fibromatous element of which, besides undergoing sarcomatous change, often ossifies or chondrifies; or by similar studies of the rarer mixed tumours of the dog's thyroid, or of other mixed tumours which may be discovered from time to time in animals. Tumours of the second class also occur in animals, e.g. embryonic renal tumours, believed to be the counterparts of the human ones, are not uncommon in pigs, rabbits and possibly birds. Analysis of the structure and properties of these by transplantation deserves further study. Such tumours not infrequently show aberrant differentiation of their tissues in part. Teratomas appear, with one exception, to be very rare in animals. The exception is the benign type of teratoma which occurs frequently in the testes of young horses. (Several examples of these were shown to the meeting.) It is a striking fact that, while dogs frequently develop seminomas, interstitial-cell tumours and Sertoli-cell tumours, teratoma of the canine testis has not been described. Ovarian teratomas are very rate in dogs, and also in rodents. But there is great need of analysis of the properties of the various components of these growths by serial -transplantation.

Teratomas and Mixed Tumours in Animals and Their Bearings on Human Pathology.[Summary]