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We designed a population-based study of the epidemiology of tuberculosis among foreign-born people in the U.S. and Canada. Challenges included standardizing recruitment and data entry at 22 sites, enrolling individuals who did not speak English and may be undocumented, and obtaining clearance from 36 institutional review boards (IRBs).

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The Challenge of Multisite Epidemiologic Studies in Diverse Populations: Design and Implementation of a 22-Site Study of Tuberculosis in Foreign-Born People