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P240 Background and Purpose: Intracranial  atherosclerotic disease (ICAD) is associated with a 7% to 10% annual  incidence of ischemic stroke. Although percutaneous transluminal  angioplasty (PTA) has been introduced for revascularization of ICAD,  the treatment experience is limited. We prospectively studied the  safety and efficacy of PTA and/or stent placement for ICAD at a  tertiary-care referral hospital.Methods: Each patient was  evaluated by a neurologist prior to, immediately following and 24 hours  after the procedure. PTA and/or stent placement were performed using  routine techniques as either single or multiple procedures. Any  complications related to the procedure in 1-month interval were  recorded. Pre- and post-angiograms were analyzed to evaluate response  to endovascular revascularization.Results: A total of 25  patients (29 procedures) were treated (mean age 62.6 ± 12.6  years) for ≥ 50% stenosis in the internal carotid artery (n=4),  middle cerebral artery (n=8), vertebral artery (n=11), or basilar  artery (n=2). The procedures included PTA (n=20), primary stenting  (n=8), or combination of both (n=1). There was an improvement in  stenosis (mean ±SD) from 85 ±13% to 23.8 ±23.4%. The overall  stroke rate per procedure was 6%; all strokes were minor. One patient  died from post-procedural intracerebral hemorrhage. Systemic bleeding  complications were observed in 6% of the procedures (3% major and 3%  minor).Conclusions: Endovascular revascularization for  treatment of ICAD appears to be feasible with a low complication rate.  Further studies are required to evaluate the long-term efficacy of  these procedures in reducing the risk of ischemic stroke in patients  with ICAD.

stroke

A Prospective Single Center Study to Evaluate Safety and Short-term Efficacy of Angioplasty and Stent Placement for Intracranial Atherosclerotic Disease