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P147 Background: Dilatation of common carotid artery  (CCA) was related to age, sex, and body height in population studies.  It was also considered a compensatory mechanism to carotid  atherosclerotic stenosis. The present study examined the risk of CCA  dilatation associated with ischemic stroke (IS) and its relations to  carotid atherosclerosis, hypertension, hyperglycemia, fibrinogen,  cholesterol, HDL-cholesterol (HDL-C), smoking, and alcohol consumption.Methods: A case-control study was carried on 251 first-ever  IS patients (age≥40) excluding previous history of myocardial  infarction and cancer and 242 non-stroke outpatients. Intraluminal  diameter of middle portion of CCA, and plaque thickness in CCA, bulb,  internal and external carotid arteries were measured. Information on  hypertension and diabetes status and data of life-styles such as  smoking and alcohol consumption were collected. Levels of fibrinogen,  factor VIIIc, cholesterol, HDL-C and glucose were obtained.Results: CCA dilatation was a strong factor for IS  (OR=4.13, P=0.0001). It was also associated with hypertension,  hyperglycemia, smoking, alcohol consumption, low HDL-C, and high levels  of fibrinogen, factor VIIIc, cholesterol, and plaque score. The  association remained significant with or without each of the following  conditions: hypertension (p=0.0001, p=0.0007), hyperglycemia (p=0.0446,  p=0.0001), elevated fibrinogen (p=0.0104, p=0.0001) or factor VIIIc  (p=0.2458, p=0.0001), hypercholesterolemia (p=0.0238, p=0.0001),  decreased HDL-C (p=0.0012, p=0.0001) and presence of plaque score  (p=0.0263, p=0.0003). Adjusting above risk factors, odds ratios of  elevated diameter could associated with IS, before (OR=2.21, P=0.0066)  and after (OR=6.63, p=0.0055) excluding subjects with plaque.Conclusion: Dilatation of CCA is a strong risk factor  for IS. The fact the association remained significant without  ultrasonic evidence of carotid plaque indicates that IS in Chinese  involved a mechanism of active vasculopathy, not just a passive  compensatory process to extracranial atherosclerosis.

Dilatation of common carotid artery is strongly associated with cerebral ischemic stroke with or without the presence of carotid atherosclerosis