English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

I write this editorial in an attempt to help applicants and their mentors as they prepare their National Heart, Lung, and Blood Institute (NHLBI)-supported K08 or K99/R00 applications. In my view, these programs are critical for the future of cardiovascular research in the United States because they support talented new investigators at a particularly vulnerable period in their careers. In this issue, Circulation Research has published an article from the NHLBI that details critical aspects of these programs.1Cardiovascular disease is still the number 1 cause of death in the United States.2 There is an obvious need to develop novel therapies to prevent or reverse the consequences of these diseases. New therapies should reduce the morbidity and mortality of cardiovascular disease, lower associated costs of health care, and improve the lives and productivity of affected patients. Basic, translational, and clinical research is the foundation on which these new therapies will be developed. High-impact discoveries that lead to medical advances are usually made by well-trained biomedical scientists, and many of these investigators have started their careers with support from NHLBI K08 (Mentored Clinical Scientist) and K99/R00 (Pathway to Independence) awards. These grants support training of young scientists in premier laboratories to prepare them for careers in what has been, in my view, the best biomedical science environment in the world, the United States. This “pipeline” of young talent is challenged by the current funding environment. In my view, the current lack of support for the biomedical research puts our leadership position in this field at risk. I digress.I have spent >25 years reviewing different types of grants for the NHLBI, and I have had significant experience both mentoring K08 awardees and reviewing K08 and K99/R00 applications. In this editorial, I give my personal views on who would make …

How to Obtain a National Heart, Lung, and Blood Institute-Sponsored K08 and K99/R00 Grant in the Current Funding Climate