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In contrast to several other studies, including the randomized controlled Symplicity-2 trial,1 renal denervation (RDN) was not associated with a blood pressure (BP) reduction in this small study by Brinkmann et al.2It is noteworthy that average baseline BP was significantly lower (157±7/85±4 mm Hg) compared with baseline levels of 178±18/97±16 mm Hg in Symplicity-2, which may explain the less pronounced BP response, given that baseline systolic BP (SBP) determines BP response.2 In contrast to Symplicity-2 inclusion criteria (SBP≥160 mm Hg, or ≥150 mm Hg if diabetic), 5 of 11 patients studied here had baseline BP levels ≤140/90 mm Hg (01:140/84 mm Hg; 05:139/71 mm Hg; 09:137/81 mm …

Blood Pressure and Sympathetic Nervous System Response to Renal Denervation