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The recent review by Komarova et al1 on Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability addresses a central topic in vascular biology that plays an important role in diabetes mellitus, cancer, and other common disorders. However, several statements in the review overlook evidence that does not support the views they promote:1. Adherens junctions are presented as the “gatekeeper of the endothelial barrier,” practically the only junction that is acutely responsive to external stimuli by undergoing turnover. This …

Letter by Horowitz Regarding Article, “Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability”