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With interest we read the review of Hecht et al1 in the July issue of Circulation Research. The authors present the technical principles and prerequisites of fractional flow reserve derived from computed tomography (CT-FFR) as a novel noninvasive technique using computational fluid dynamics to calculate FFR from standard coronary computed tomography angiography data sets without the administration of a pharmacological stress agent or repeat CT acquisitions. In several large trials, the feasibility of CT-FFR has been proven with promising results. It was demonstrated that the technique primarily improves the specificity and positive predictive value of CT, while the test’s traditionally high sensitivity and negative predictive value are preserved. A substantial correlation with invasive FFR has also been shown.Although the technique was approved by the Food and Drug Administration in late 2014, the exact use and benefit of this …

Letter by Baumann et al Regarding Article, “Fractional Flow Reserve and Coronary Computed Tomographic Angiography: A Review and Critical Analysis”