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Deficiency of secreted IgM (sIgM -/- ) accelerates atherosclerosis in Ldlr -/- mice. Several atheroprotective effects of increased levels of IgM antibodies have been suggested, including preventing inflammation induced by oxidized low-density lipoprotein and promoting apoptotic cell clearance. However, the mechanisms by which the lack of sIgM promotes lesion formation remain unknown.

Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency