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With great interest we have read the article by Cogle et al1 recently published in this journal. The article describes a detailed analysis of bone marrow cells obtained from close to 300 patients enrolled in a triplet of clinical trials investigating bone marrow cells as potential therapy for ischemic heart disease. One of the analyses performed in the study is a colony forming assay for endothelial colony forming cells (ECFCs), a type of endothelial progenitor cells usually obtained from blood and thought to be of importance for vascular homeostasis and repair.2The …

circulation research

Letter Regarding the Article, “A Detailed Analysis of Bone Marrow From Patients With Ischemic Heart Disease and Left Ventricular Dysfunction: BM CD34, CD11b, and Clonogenic Capacity as Biomarkers for Clinical Outcomes”