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The sodium-calcium exchanger 1 (NCX1) is predominantly expressed in the heart and is implicated in controlling automaticity in isolated sinoatrial node (SAN) pacemaker cells, but the potential role of NCX1 in determining heart rate in vivo is unknown.

circulation research

Genetic Inhibition of Na <sup>+</sup> -Ca <sup>2+</sup> Exchanger Current Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart Rate

Genetic Inhibition of Na + -Ca 2+ Exchanger Current Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart Rate

Genetic Inhibition of Na ⁺ -Ca ²⁺ Exchanger Current Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart Rate