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The nationwide metoprolol extended release shortage in the United States was associated with fewer patients receiving any long- or short-acting β-blocker post-MI and lower adherence to β-blocker therapy for those who did receive it, but did not appear to appreciably affect clinical outcomes at the population level.

Impact of a Metoprolol Extended Release Shortage on Post-Myocardial Infarction β-Blocker Utilization, Adherence, and Rehospitalization