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Failing hearts display slow relaxation with apparent increased load sensitivity. However, inaccuracies of monoexponential analysis can contribute to these observations, and different qualitative and quantitative results might be obtained by alternative models. We tested whether pressure relaxation of failing hearts consistently deviates from a monoexponential waveform, leading to overestimations of lusitropic change and load sensitivity by monoexponential-derived time constants.

Analysis of Isovolumic Relaxation in Failing Hearts by Monoexponential Time Constants Overestimates Lusitropic Change and Load Dependence