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High intensity focused ultrasound (HIFU) has been introduced for treatment of cardiac arrhythmias because it offers the ability to create rapid tissue modification in confined volumes without directly contacting the myocardium. In spite of the benefits of HIFU, a number of limitations have been reported, which hindered its clinical adoption.

Three Potential Mechanisms for Failure of High Intensity Focused Ultrasound Ablation in Cardiac Tissue