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Mild brain hypothermia significantly alleviates damage after focal ischemia, although the mechanism of this protection remains poorly defined. In the present study, we tested the hypothesis that mild hypothermia would protect cortex from early deterioration of ion homeostasis and loss of excitability associated with reperfusion after focal ischemia.

Mild Hypothermia Improves Recovery of Cortical Extracellular Potassium Ion Activity and Excitability After Middle Cerebral Artery Occlusion in the Rat