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Homocysteine (Hcy)-thiolactone mediates protein N-homocysteinylation in humans. Protein N-linked Hcy comprises a major pool of Hcy in human blood, greater that the "total" Hcy pool. N-homocysteinylated proteins are structurally different, compared with native proteins, and are thus likely to be recognized as neoself antigens and induce an autoimmune response. This study was undertaken to provide evidence for anti-Nepsilon-Hcy-Lys-protein antibody and to examine associations between the antibody level, Hcy, and stroke in humans.

Autoantibodies Against N -Homocysteinylated Proteins in Humans