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Transitions in cardiac myosin isotypes occur in response to a variety of stimuli. These are well documented in small, but less so in larger, mammals where data on quantitative isotype composition of normal atria and ventricles are scarce. In this study, heavy and light chain isotypes were examined in fetal, neonatal, and adult bovine and human hearts. Defined anatomical areas of chambers were studied, and detailed mapping of isotypes was conducted on bovine atria. Heavy chain isotype quantification was carried out electrophoretically either after peptide mapping or by a new technique for separating whole cardiac alpha- and beta-heavy chains capable of detecting 5% of either isotope. Atrial and ventricular light chains were resolved electrophoretically, and all isotypes were quantified densitometrically. Beta-Heavy chain was almost exclusively expressed (greater than 95%) in the ventricles at all ages except in the bovine neonate. Ventricular light chains predominated in the adult ventricle, but atrial light chain 1 was present at mid-gestation. This was replaced by ventricular light chain 1 in the neonate with no transitions in light chain 2 isotypes. Transitions were more marked in the atria. Only alpha-heavy chains were detected at mid-gestation, but beta-heavy chain increased toward birth. After a decline in the neonatal period, beta-heavy chain levels usually increased in the adult. Atrial light chains were the main isotypes in the atria, but ventricular light chain 2 was the major adult bovine atrial isotype. Transitions in isotypes were significant at birth as in smaller mammals. No close relationship existed between heavy and light chain transitions. Significant anatomical variation in bovine atrial isotype expression was present, and may reflect functional demand in each area.

Myosin transitions in the bovine and human heart. A developmental and anatomical study of heavy and light chain subunits in the atrium and ventricle.