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Recently, Witte et al. (1983) reported data on transcapillary water and protein flux in intestine from dogs with acute and chronic extrahepatic portal hypertension. Meaurements were made of lymph flow and total protein concentration in lymph and plasma. Additionally, plasma disappearance rate of radioiodinated albumin was determined in some animals. From these experiments, the authors concluded that about 80% of the transcapillary protein flux in control dogs was convective-filtrative, while a dissipative process (diffusion) was responsible for the rest. During both acute and chronic portal pressure elevation there was a shift from convective to diffusive protein transfer: diffusive fraction increased from 20% to 40% and convective fraction decreased from 80% to 60%. No relationship was found between transcapillary protein flux and portal pressure. In contrast to these experiments, we have estimated the transcapillary albumin flux from the plasma disappearance rate of radioiodinated albumin (Henriksen et al., 1981) in control pigs and during acute extrahepatic portal hypertension. As shown in Figure 1, the overall plasma clearance of albumin (plasma volume X fractional disappearance rate) was closely related to portal pressure. This indicates, to us, that convective-filtrative transcapillary albumin flux is dominant also during elevated portal pressure. In our experiments, the increase in albumin clearance was on the average three times that of Witte et al. (34 vs. 11 ^I/miri per kg), a finding which may, at least in part, be explained by the much larger digestive tract in pigs compared to dogs.

Comments on "Transcapillary water and protein flux in the canine intestine with acute and chronic extrahepatic portal hypertension".