English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

SUMMARY Carotid sinus baroreceptor nerve activity was examined in eight renal hypertensive dogs with a duration of hypertension of 5 to 82 days and a mean blood pressure of 148 ± 0.5 mm Hg. These results were compared with those from 13 normotensive dogs. Whole carotid sinus nerve activity and single fiber activity were recorded in the isolated carotid sinus preparation in response to controlled static and pulsatile pressures. Stimulusresponse curves were constructed. Single fiber adapted (5-second) threshold pressure under static pressure conditions increased from 104 ± 3.2 mm Hg in the normotensive dogs to 128 ± 3.9 mm Hg in the hypertensive dogs. Inflection pressure and plateau pressure also were higher in hypertension. Impulse frequency at the inflection pressure was reduced from 39 ± 2.3 impulses/sec in normotensive dogs to 32 ± 1.7 impulses/sec in hypertensive dogs and, at the plateau pressure, from 43 ± 2.1 impulses/sec to 34 ± 1.9 impulses/sec. Whole nerve recordings also showed significantly higher threshold, inflection, and plateau pressures in the hypertensive dog. In response to pulsatile pressure, the single fiber sensitivity decreased from 0.17 ± 0.01 to 0.11 ± 0.01 impulses/cycle per mm Hg. Continuous nerve activity under these conditions occurred at a mean pressure of 166 ±3. 5 mm Hg for the normotensive dogs, compared with 188 ± 0.4 mm Hg for the hypertensive dogs. Hypertensive dogs showed an impulse frequency identical to that of normotensive dogs at pressures equivalent to each dog's unanesthetized mean blood pressure. Baroreceptor resetting was not seen before 5 days of hypertension. It was possible to reverse the resetting by lowering the blood pressure in one dog which had been hypertensive for 47 days.

Characteristics of single carotid sinus baroreceptor fibers and whole nerve activity in the normotensive and the renal hypertensive dog.